Family Studies of Cleft Lip and Cleft Palate (Mary Marazita; 4/8/10)
Abstract: This research seminar discusses the genetics of cleft lip and palate. Nonsyndromic oral clefts are common congenital anomalies that result from defects during embryonic development. Many genes and signaling pathways are involved in causing these anomalies during craniofacial development. We will discuss several responsible genes that have been identified so far, as well as the types of studies used to elucidate the etiology of cleft lip and palate.
Keywords: cleft palate; cleft lip; genetics; phenotype; craniofacial development; genome-wide association studies
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