Email
arv11@dental.pitt.edu

Phone
412-383-8972

Office
614 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261

Position
Assistant Professor, Department of Oral Biology
School of Dental Medicine

Research Interests

1. Dental Anomalies as an Extended Phenotype for Clefts:  We are working on collecting detailed clinical information of cleft families to include dental anomalies as part of the cleft phenotype in the genetics analysis. This work is funded by the NIH/NIDCR grant R21-DE016718. We also will investigate cancer susceptibility of cases with oral clefts and tooth agenesis.
2. Genetics of Caries:  We are investigating the genetics contribution on caries by accessing individuals caries free or with low caries experience and comparing them to individuals with very high caries experience.
3. Genetics of Periodontal Diseases:  In one aspect of this project we are working on mapping and cloning the aggressive periodontitis gene. We will apply these findings in further studies of the chronic type of the periodontal diseases. In another aspect of this project we are interested in the relationship of periodontal diseases with maternal outcomes, such as prematurity and low birth weight. We are setting up a collaboration to collect samples from a cohort of pregnant women in Brazil to explore the disparities seem in prematurity prevalence in African descents.
4. Dental Registry and DNA Repository:  We have established the Dental Registry and DNA Repository (DRDR), at the School of Dental Medicine in order to obtain clinical information and a biological sample from all individuals seeking treatment at the School of Dental Medicine. The Dental Registry and DNA Repository is revolutionary because it eliminates the need for further Institutional Review Board (IRB) evaluations for projects seeking to use data from the registry.  Furthermore, the DRDR will allow the clinical faculty to engage in research activities and to increase the external funding for research at the School of Dental Medicine. To our knowledge, the SDM Clinical Registry and DNA Repository will be the only project in the world to keep a comprehensive set of dental phenotypes linked to DNA samples.
   • Dental Registry and DNA Repository (DRDR)
   • Vieira Lab

Recent Publications

Vieira AR, Modesto A, Meira R, Barbosa AR, Lidral AC, Murray JC. Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis. Am J Med Genet A. 2007 Feb 22;143A(6):538-545.

Pardo ARV, Castillo ST, Vieira AR. Genetic studies of a Chilean family with three different dental anomalies. Rev Med Chile 2006 Dec; 134(12):1541-1548.

Avila JR, Jezewski PA, Vieira AR, Orioli IM, Castilla EE, Christensen K, Daack-Hirsch S, Romitti PA, Murray JC. PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations. Am J Med Genet A. 2006 Dec 1;140(23):2562-70.

Warrington A, Vieira AR, Christensen K, Orioli IM, Castilla EE, Romitti PA, Murray JC. Genetic evidence for the role of loci at 19q13 in cleft lip and palate. J Med Genet 2006 Jun;43(6):e26.

Neiswanger K, Deleyiannis FW, Avila JR, Cooper ME, Brandon CA, Vieira AR, Noorchashm N, Weinberg SM, Bardi KM, Murray JC, Marazita ML. Candidate genes for oral-facial clefts in Guatemalan families. Ann Plast Surg. 2006 May;56(5):518-21; discussion 521.

Vieira AR. Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review. Am J Epidemiol. 2006 May 1;163(9):790-810.

Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, Felix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC. Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet. 2005 Dec;1(6):e64.

Vieira AR, Murray JC, Trembath D, Orioli IM, Castilla EE, Cooper ME, Marazita ML, Lennon-Graham F, Speer M. Studies of reduced folate carrier 1 (RFC1) A80G and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with neural tube and orofacial cleft defects. Am J Med Genet A. 2005 Jun 1;135(2):220-3.

Vieira AR, Castillo Taucher S. [Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly] Rev Med Chil. 2005 Jan;133(1):62-70.

Vieira AR, Castillo Taucher S, Aravena T, Astete C, Sanz P, Tastets ME, Monasterio L, Murray JC. [Mutational analysis of the muscle segment homeobox gene 1 (MSX1) in Chilean patients with cleft lip/palate] Rev Med Chil. 2004 Jul;132(7):816-22.

Vieira AR, Meira R, Modesto A, Murray JC. MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. J Dent Res 2004 Sep; 83(9):723-7.

Zucchero TM, Cooper ME, Maher BS, Daack-Hirsch S, Nepomuceno B, Ribeiro L, Caprau D, Christensen K, Suzuki Y, Machida J, Natsume N, Yoshiura K, Vieira AR, Orioli IM, Castilla EE, Moreno L, Arcos-Burgos M, Lidral AC, Field LL, Liu YE, Ray A, Goldstein TH, Schultz RE, Shi M, Johnson MK, Kondo S, Schutte BC, Marazita ML, Murray JC. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med. 2004 Aug 19;351(8):769-80.

Vieira AR. Birth order and neural tube defects: a reappraisal. J Neurol Sci. 2004 Jan 5;217(1):65-72.