Mark P. Mooney, PhD


Email
mpm4@pitt.edu

Phone
412-648-8833; 412-648-8505

Office
347 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261

Position
Professor and Chair

Department of Oral Biology
School of Dental Medicine

Research Interests

  • Normal and pathological suture morphogenesis and biology.
  • Bone tissue engineering and regeneration. Development of animal models for bone tissue engineering. Phenotypic variability and morphology in individuals with craniofacial anomalies. Evolutionary changes in the primate craniofacial complex.
  • Biological and cultural adaptations to extreme environments.

Recent Publications

Premaraj S, Mundy B, Morgan D, Winnard PL, Mooney MP, Moursi AM. Sustained delivery of bioactive cytokine using a dense collagen gel vehicle. Archives of Oral Biology, 2006; 51: 325-333.                                           

Cooper, G.M., Singhal, V.K., Barbano, T., Wigginton, W., Rabold, T. Losken, H.W., Siegel, M.I., Mooney, M.P. Intracranial volume changes in craniosynostotic rabbits: Effects of age and surgical correction. Plastic and Reconstructive Surgery, 2006;117:1886-1890

Weinberg, S.M. Neiswanger, K., Martin R., Mooney, M.P., Kane, A., Wenger, S., Losee, J., Deleyiannis, F., Tunçbilek, G., Ma, L.,  De Salamanca, J.E., Czeizel, A., Marazita, M.L. The Pittsburgh Oral-Facial Cleft (POFC) Study: Expanding the cleft phenotype. Part 1. Justification and study design. Cleft Palate-Craniofacial J., Cleft Palate Craniofac J 2006; 43: 7-20

Caccamese, Jr., J. F., Costello, B.J., Mooney, M.P. A novel deformity of the mandible in oculoauriculovertebral spectrum: a case report and literature review. J. Oral and Maxillofacial Surgery, 2006; 64: 1278-1282.

Fellows-Mayle, W., Hitchens, T.K., Simplaceanu, E., Horner, J., Barbano, T., Losee, J.E., Losken, H.W., Siegel, M.I., Mooney, M.P. Testing causal mechanisms of nonsyndromic craniosynostosis using path analysis of cranial contents in rabbits with uncorrected craniosynostosis. Cleft Palate-Craniofac. J.,. 2006; 43: 524-531.

Downey PA, Barbano T, Rupali K, Sciote JJ, Siegel MI,  Mooney MP. Craniosacral therapy: The effects of cranial manipulation on intracranial pressure and cranial bone movement.  J. Orthop Sports Phys Ther. 2006; 36: 845-853.

Dudas JR, Losee JE, Cooper GM, Penascino VM, Mooney MP, Jiang S, Rubin JP, and Marra KG.  The Osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects.  Annals of Plastic Surgery, 2006; 56:543-548.

Gabbay JS, Heller J, Spoon DB, Mooney MP, Acarturk O, Askari M, Wasson KL, Bradley JP. Noggin underexpression and runx-2 overexpression in a craniosynostosis rabbit model. Ann Plast Surg, 2006; 56:306-31.

Mooney, M.P., Losken, H.W., Moursi, A., Bradley, J., Azari, K., Acarturk, O., Cooper, G.M., Thompson, B., Opperman, L.A., Siegel, M.I., Anti-Tgf-β2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits. Plast Reconstr Surg, 2007; 119: 1200-1212.

Losee JE, Mason AC,  Dudas J,  Hua LB, Mooney MP. Non-synostotic occipital plagiocephaly:  Factors impacting onset, treatment, and outcomes. Plast Reconstr Surg, 2007; 119:1866-1873.

Nair MK, Nair UP, Seyedain A, Gassner R, Piesco N, Mooney MP, Ganta S, Agarwal S.Correlation of Tuned Aperture Computed Tomography (TACT) with Computed Tomography (CT) for evaluation of osseous healing in calvarial defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007:103:267-273. 

Smith, T. D.,. Bhatnagar, K. P., Rossie,J. B.,  Docherty, B.A.,. Burrows, A.M., Cooper, G.M., Mooney, M.P., Siegel, M.I. . Scaling of the first ethmoturbinal in nocturnal strepsirrhines: olfactory and respiratory surfaces Anatomical Record, 2007; 290: 215-237.  

Cooper G.M., Curry C., Barbano T., Burrows A.M., Vecchione L., Caccamese J., Norbutt C., Costello B.J., Losee J.E., Moursi A.M., Huard J., Mooney M.P. Noggin inhibits postoperative resynostosis in craniosynostotic rabbits. J. Bone Miner. Res., 2007; 22: 1046-1054.          

Vecchione, L., Byron, C., Cooper, G.M., Barbano, T., Hamrick, M.W. Sciote, J.J., Mooney, M.P. Craniofacial morphology in myostatin deficient mice. J. Dent. Res., 2007; 86:1068-1072.

Neiswanger, K., Weinberg, S.M.,  Rogers, C.R.,  Brandon, C.A., Cooper, M.E., Bardi, K.M.,  Deleyiannis, F.W.B., Resick, J.M., Bowen, A.D., Mooney, M.P., Enríquez de Salamanca, J., González, B., Maher, B.S., Martin, R.A., Marazita, M.L. Orbicularis oris muscle defects as an expanded phenotypic feature in nonsyndromic cleft lip with or without cleft palate. Am J Med Genet A. 2007;143A(11):1143-1149.

Mooney, M.P., Losken, H.W., Moursi, A., Shand, J.M., Cooper, G.M., Curry, C., Ho, L, Burrows, A.M., Stelnicki, E.J., Losee, J.E., Opperman, L.A., Siegel, M.I., Postoperative anti-TGF-2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. J. Craniofac Surg, 2007; 18: 336-346.

Carmody, K.A., Mooney, M.P., Cooper, G.M., Bonar, C.J., Siegel, M.I., Dumont, E., Smith, T.D. Relationship of premaxillary bone and its sutures to deciduous dentition in non-human primates. Cleft Palate Craniofac J., 2008; 45: 93-100.

Dudas JR, Losee JE, Penascino V, Smith DM, Cooper GM, Mooney MP, Jiang S, Rubin JP, Marra KG. Leporine-derived Adipose Progenitor Cells Exhibit Osteogenic Properties In Vitro. J Craniofac Surg, 2008; 19(2):360-368.

Losken, H.W., van Aalst, J.A., Mooney, M.P., Godfrey, V.L., Burt, T., Teotia, S., Dean S.B., Moss, J.R., Rhabar, R. Biodegradation of Inion fast absorbing biodegradable plates and screws. J. Craniofacial Surgery,  2008;19:748-756.

Frazier B, Mooney MP, Losken HW, Barbano T, Moursi A, Siegel MI, Richtsmeier J. Comparison of craniofacial phenotype in craniosynostotic rabbits treated with Anti-Tgf-beta2 at suturectomy site. Cleft Palate Craniofac J. 2008;45:571-582.

Rogers CR, Weinberg SM, Smith TD, Deleyiannis FW, Phil M, Mooney MP, Marazita ML. Anatomical basis for apparent subepithelial cleft lip: a histological and ultrasonographic survey of the orbicularis oris muscle. Cleft Palate Craniofac J. 2008; 45: 518-524.

Weinberg SM, Neiswanger K,  Richtsmeier JT, Maher BS, Mooney MP, Siegel MI, Marazita ML. Three-Dimensional Morphometric Analysis of Craniofacial Shape in the Unaffected Relatives of Individuals with Nonsyndromic Orofacial Clefts: A Possible Biomarker for Genetic Susceptibility. American Journal of Medical Genetics Part A. 2008; 146A: 409-420.

Losee JE, Smith DM, Jiang S, Ford M, Vecchione L, Cooper GM, Gilmore J, Naran S, Mooney MP. A successful algorithm for limiting post-operative fistulae following palatal procedures in the patient with orofacial clefting. Plast Reconstr Surg, 2008;122:544-554.   

Smith DM, Cooper GM,  Mooney MP, Marra KG, Losee JE. Bone morphogenetic protein 2 therapy for craniofacial surgery. J Craniofac Surg, 2008;19:1244-1259.

Smith DM, Affifi AM, Cooper GM, Mooney MP, Marra KG, Losee JE. BMP-2-based repair of large-scale calvarial defects in an experimental model: Regenerative surgery in cranioplasty. J. Craniofac Surg, 2008; 19: 1315-1322.

Mooney MP. Classification of orofacial clefts. In Losee JE, Kirschner RE (eds.): Comprehensive Cleft Care. New York, McGraw-Hill Publishing, 2008, 21-34.

Costello, B.J., Mooney, M.P., Shand, J. Chaper 43. Craniomaxillofacial surgery in the pediatric patient:  Growth and development considerations. In: Turvey, TA, Scully RJ, Waite PD, Costello BJ, Ruiz R.(eds): Oral and Maxillofacial Surgery, Second Edition, Volume III. Orthognathic Surgery, Esthetic Surgery, Cleft and Craniofacial Surgery,  New York, Saunders, 2009; 848-863.

Cooper, G.M., Usas, A., Olshanski, A., Mooney, M.P., Losee, J.E., Huard, J. Ex vivo noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis.  Plast. Reconstr. Surg., 2009; 123(Suppl 2): 94S-103S.

Rogers CR, Mooney MP, Smith TD, Weinberg SM, Waller BM, Parr LA, Bonar CJ, Docherty BA, Reinholdt LE, Deleyiannis FWB, Siegel MI, Marazita ML, Burrows AM.  Comparative micro-anatomy of the orbicularis oris muscle in chimpanzees and humans:  Evolutionary divergence of lip function. J. Anat. 2009; 214(1): 36-44.

Foley L, Fellows-Mayle W, Hitchens TK,  Losee J, Barbano T, Siegel MI, Mooney MP. Age-related peridural hyperemia in craniosynostotic rabbits. Child’s Nervous System.  2009; 25:861-866.

Vecchione L,  Miller, J., Byron C, Cooper GM, Barbano T, Cray JJ, Losee JE, Hamrick MW, Sciote JJ, Mooney MP. Age Related Changes in Craniofacial Morphology in GDF-8 (Myostatin) Deficient Mice. Anat Rec. 2010; 293: 32-41.

Smith TD, Rossie JB, Cooper GM, Carmody KA, Schmieg RM, Bonar CJ, Mooney MP, Siegel MI. Ontogentic study of the maxillary sinus in three genera of New World monkeys: Factors that constrain secondary pneumatization. Anat. Rec. 2010; 293: 91-107.