DMD, PhD, DDS
Dr. Hongjiao Ouyang, DDS/DMD, PhD, is a tenured Associated Professor and licensed endodontist of the Departments of Comprehensive Care and Restorative Dentistry and Oral Biology, School of Dental Medicine (SDM) of the University of Pittsburgh. Dr. Ouyang is also a faculty member of the Center of Craniofacial Regeneration (CCR), SDM, the Molecular and Cellular Cancer Biology program and Tumor Microenvironment Center of the University of Pittsburgh Cancer Institute (UPCI) as well as the McGowan Institute for Regenerative Medicine, the University of Pittsburgh.
She obtained her DDS and DMD from the School of Stomatology, Sichuan University, P.R. China and SDM of the University of Pittsburgh in 1993 and 2008 respectively. In addition, she obtained her PhD and endodontic certificate from the School of Dentistry, the University of Michigan, Ann Arbor, Michigan, in 2000 and 2002, respectively.
Dr. Ouyang is a molecular biologist/bone biologist who runs an NIH-funded research laboratory - THE LABORATORY OF SIGNAL TRANSDUCTION OF MINERALIZED TISSUE DEVELOPMENT, HOMEOSTASIS AND DISEASES. The laboratory investigates molecular and cell mechanisms underlying the development, homeostasis, and diseases of mineralized tissues and to identify promising therapeutic targets to treat oral diseases and systemic diseases with prominent craniofacial manifestations, focusing on endoplasmic reticulum (ER) stress, Wnt and Mammalian Target of Rapamycin (mTOR) signaling. In addition, Dr. Ouyang's research team is dedicated to understand whether and how key developmental regulators of bone development and hemostasis modulate bone microenvironment support of tumor bone metastasis, focusing on multiple myeloma bone disease, one of most devastating tumor bone disease that heavily affects craniofacial structures.
Dr. Ouyang serves on several positions at both national and international levels, such as Scientific Advisory Board of Journal of Endodontics (JOE), a member of the American Association of Dental research (AADR) Fellowship Committee, Councilor of the Mineralized Tissue Biology branch of AADR and Vice President of the AADR Pittsburgh Chapter.