Key Faculty

Study PI's
Mary Marazita
Robert Weyant

Richard Crout
Levent Kirisci
Daniel McNeil
Deborah Polk
Ralph Tarter
John Thomas






Richard Crout, DMD, PhD
See also
Richard Crout

Professor, Associate Dean for Research, School of Dentistry
Professor of Biochemistry and Molecular Pharmacology, School of Medicine
G 110 B Health Sciences North
PO Box 9448
Morgantown, WV 26506-6290
E-mail: rcrout@hsc.wvu.edu

My research interests lie in the areas of pharmacology, periodontics and oral health disparities. Research projects in pharmacology have included evaluations of local anesthetics, narcotic analgesics and immunmodulators. Periodontic research has included topical drug activity, diagnostics utilizing crevicular fluid and the development of a model to evaluate chemotherapeutic solutions for topical debridement.

Recent Publications

Lee HM, Golub LM, Chan D, Leung M, Schroeder K,Wolff M, Simon S, Crout R. alpha 1-proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline. J Periodontol Res. 1997 Jan;32(1 Pt 1):9-19.

Moore PA, Crout RJ, Jackson DL, Schneider LG, Graves RW, Bakos L. Tramadol hydrochloride: analgesic efficacy compared with codeine, aspirin with codeine, and placebo after dental extraction. J Clin Pharmal. 1998 Jun;38(6):554-60.

Thomas JG, Metheny RJ, Karakiozis JM, Wetzel JM, Crout RJ. Long-term sub-antimicrobial doxycycline (Periostat) as adjunctive management in adult periodontitis: effects on subgingival bacterial population dynamics. Adv Dent Res. 1998 Nov;12(2):32-9.

Caton JG, Ciancio SG, Bleiden TM., Bradshaw M, Crout RJ, Hefti AF, Massaro JM, Polson AM, Thomas J, Walker C. Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planning in patients with adult periodontitis. J Periodontol. 2000 Apr;71(4):521-32.

Kohli K, Ngan P, Crout R, Linscott CC. A survey of local and topical anesthesia use by pediatric dentists in the United States. Pediatr Dent. 2001 May-Jun;23(3):265-9.

Frere CL, Crout R, Yorty J, McNeil DW. Effects of audiovisual distraction during dental prophylaxis. J Am Dent Assoc. 2001 Jul;132(7):1031-8.

Caton JG, Ciancio SG, Bleiden TM, Bradshaw M, Crout RJ, Hefti AF, Massaro JM, Polson AM, Thomas J, Walker C. Subantimicrobial dose doxycycline as an adjunct to scaling and root planning: post-treatment effects. J Clin Periodontol. 2001 Aug;28(8):782-9.

Price S, Crout R, Yorty J, Wearden S. Evaluation of a dental school’s advising system. J Dent Ed. 2002 66(2):269-70.

Levent Kirisci, PhD
See also
Levent Kirisci

Associate Professor
University of Pittsburgh School of Pharmacy
707 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261
E-mail: levent@pitt.edu

Using item response theory and structural equation modeling, Dr. Kirisci's research focus is the development of psychometrically sound instruments utilized in substance abuse and psychiatric research. More recently, he has developed "Substance Abuse Liability Index" and "Substance Use Severity Index" in collaboration with the Center for Education and Drug Abuse Research (CEDAR) faculty.

Recent Publications

Kirisci, L., Tarter, R.E., Vanyukov, M., Reynolds, M., & Habeych, M. Relation between cognitive distortions and neurobehavior disinhibition on the development of substance use during adolescence and substance use disorder by young adulthood: A prospective study. Drug and Alcohol Dependence, 76, 125-133, 2004.

Kirisci, L., Vanyukov, M., & Tarter, R. Detection of youth at high risk for substance use disorders: A longitudinal study. Psychology of Addictive Behaviors, 19, 243-252, 2005.

Kirisci, L., Ali A. Al-Subaihi, Tarter, R. Effects of Generalized Box-Cox Transformation on Type I Error Rate and Power of Hotelling's T2. Journal of Statistical Computation and Simulation, 75 (3), 199-206, 2005.

Salloum, I., Cornelius, J., Daley, D., Kirisci, L., Himmelhock, J., & Thase, M. Efficacy of Valproate Maintenance In Bipolar Alcoholics: A Double Blind Placebo Controlled Study. Archives of General Psychiatry, 62, 37-45, 2005.

Feske, U., Tarter, R.E., Kirisci, L., & Pilkonis, P.A. Borderline Personality and Substance Use in Women. The American Journal on Addictions, 15, 131-137, 2006.

Kirisci, L., Tarter, R., Reynolds, M., & Vanyukov, M. Individual differences in childhood neurobehavior disinhibition predict decision to desist substance use during adolescence and substance use disorder in young adulthood: A prospective study. Addictive Behaviors, 31, 686-696, 2006.

Kirisci, L., Tarter, R.E., Vanyukov, M., Martin, C., Mezzich, A., & Brown, S. Application of item response theory to quantify substance use disorder severity. Addictive Behaviors Special Issue "Novel Approaches to Phenotyping Drug Abuse", 2006.

Martin, C., Chung, T., Kirisci, L., & Langenbucher, J. An Item Response Theory Analysis of Diagnostic Criteria for Alcohol and Cannabis Use Disorders in Adolescents: Implications for DSM-V. Journal of Abnormal Psychology, in press.

Mary Marazita
See also
Mary Marazita

Daniel McNeil
See also
Daniel McNeil

Deborah Polk, PhD

Assistant Professor of Dental Public Health
University of Pittsburgh School of Dental Medicine
381 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261
E-mail:
dpolk@pitt.edu

Our lab examines how psychological factors “get inside” the body and affect physical health. We are particularly interested in the roles of socioeconomic status, psychosocial stress, and social relationships in oral health outcomes such as periodontal disease. Our work focuses on inflammatory pathways and their regulators, including the hypothalamic-pituitary-adrenal axis.

Recent Publications

Gump BB, Polk DE, Kamarck TW, Shiffman SM. Partner interactions are associated with reduced blood pressure in the natural environment: Ambulatory monitoring evidence from a healthy, multiethnic adult sample. Psychosom Med. 2001 May-Jun;63(3):423-33.

Polk DE, Kamarck TW, Shiffman S. Hostility explains some of the discrepancy between daytime ambulatory and clinic blood pressures. Health Psychol. 2002 Mar;21(2):202-6.

Kamarck TW, Polk DE, Sutton-Tyrrell K, Muldoon MF. The incremental value of ambulatory BP persists after controlling for methodological confounds: Associations with carotid atherosclerosis in a healthy sample. J Hypertens. 2002 Aug;20(8):1535-41.

Kamarck TW, Janicki DL, Shiffman S, Polk DE, Muldoon MF, Liebenauer LL, Schwartz JE. Psychosocial demands and ambulatory blood pressure: A field assessment approach. Physiol Behav. 2002 Dec;77(4-5):699-704.

Polk, DE, Cohen, S, Doyle, W.J., Skoner, D. P., and Kirschbaum, C. State and trait affect as predictors of salivary cortisol in healthy adults. Psychoneuroendocrinology. 2005 Apr;30(3):261-272.

Ralph Tarter
See also
Ralph Tarter

John G. Thomas, PhD
See also
John Thomas

Professor
West Virginia University Health Sciences Center North
Department of Pathology
PO Box 9203, Room 2114
Morgantown, WV 26506-9203
E-mail: jthomas@hsc.wvu.edu

Dr. John G. Thomas's world-wide studies and travels, in an array of disciplines, have led to his unique knowledge and diversified interests that have developed into his current focus on translational studies that bridge the gap between research scientists and clinical practitioners. His focus is on the investigation of the nature of dental/medical biofilms: particularly the microbiology of plaque and biofilm development on indwelling medical devices such as endotracheal tubes. In 1999 he added the Mountain State-Oral Facial Microbiology Laboratory, one of only seven Fee-for-Service Dental Laboratories incorporating the strengths and diagnostic skills of a traditional diagnostic laboratory with a research laboratory, establishing a link between oral hygiene and lung infections Dr. Thomas is also a co-investigator for the Centers for Research to Reduce Oral Health Disparities (COHRA) under RFA: DE-99-003 supported by NIDR, a 7-year bi-university consortium (University of Pittsburgh) studying Oral Heal and Disparity in Appalachia. He is also the PI of the Supplemental Grant submitted in November 2005, entitled "Community and Family Contextual Influence on Oral Health."

His journey began in Vermont with a Bachelor of Science at Norwich University and then to Syracuse University, where he received his Masters and Ph.D. He completed his residency as a Captain in the United States Army, Medical Service Corp where he was the Director Microbiology/Virology at Letterman General Hospital in San Francisco, California. Dr. Thomas has been at West Virginia University since 1993 as a Pathology/Microbiology Professor for the School of Medicine, Clinical Professor for Periodontics at the School of Dentistry, and an Adjunct Professor for the Graduate School, Department of Microbiology, Immunology, and Cell Biology, as well as for the School of Pharmacy. He is also the Director of Biofilm Research Laboratory and Director of Microbiology and Virology in the Clinical Laboratories at WVU Hospitals.

Recent Publications

Ramadan, H., Sanclement, J., Thomas, J. Chronic Rhinosinusitis and Biofilms. Otolaryngology Head Neck Surg 2005;132:414-7.

Sanclement, J., Webster, P., Thomas, J., and Ramadan, H. Bacterial Biofilms in Surgical Specimens of Patients with Chronic Rhinosinusitis. Laryngoscope 1994;115:578-582.

Thomas, J. Biofilms. APIC Epidemiology. 2005;96:1-13.

Thomas, J., Ramage, G., Lopez-Ribot, J. Biofilms and Implant Infections. Microbial Biofilms 2004;269-460.

Thomas, J., Lynton, I., Rinde, H. Economic Impact of Biofilms on Treatment Costs. Biofilm Infec Antimicrob Therapy. 2005;21-37.

Robert Weyant, DMD, DPH

Professor and Chair, Department of Dental Public Health
University of Pittsburgh School of Dental Medicine
346 Salk Hall
3501 Terrace Street
Pittsburgh, PA
412-648-3076
E-mail:
rjw1@pitt.edu

Dr. Robert Weyant is Professor and Chair of the Department of Dental Public Health at the University of Pittsburgh¹s School of Dental Medicine. Dr. Weyant’s research involves basic epidemiological research of oral health disparities. He is presently director of the Center for Oral Health Research in Appalachia (COHRA), and Co-PI of the affiliated NIH-funded study of oral disease etiology in rural families in Appalachia. Dr. Weyant is studying the social epidemiology of oral disease in his Appalachian families, including the influence of income, education, and social networks on oral disease development. Additionally, Dr. Weyant is pursuing the development of interventions to reduce oral disease in difficult to reach populations, such as the rural poor.

Previously, Dr. Weyant has had NIH funding to study oral and systemic disease connections in older adults, including the effects of osteoporosis, body mass changes, type II diabetes, and quality of life.

Additionally, Dr. Weyant is involved in developing community dental programs for the city of Pittsburgh and the Commonwealth of Pennsylvania as a consultant to the local and state health departments. These include a countywide dental sealant program and a statewide oral health needs assessment.

Dr. Weyant is a past president of the American Association of Public Health Dentistry and involved in dental public health education.

Dr. Weyant received both an M.S. (1978) from the Graduate School of Public Health and D.M.D. (1982) from the School of Dental Medicine at the University of Pittsburgh. Upon serving four years as a dental officer in the U.S. Navy, Dr. Weyant completed a residency in Dental Public Health (certificate) in 1986 with the Department of Veteran’s Affairs. In 1991 Dr. Weyant was awarded a doctoral degree in epidemiology from The University of Michigan. Dr. Weyant has been a diplomate of the American Board of Dental Public Health since 1987.

Recent publications

Weyant RJ. Report of recommendations from the National Dental Public Health Workshop, February 10-12, 2002. J Public Health Dent. 2003 Fall;63(4):258-62.

Lee JS, Weyant RJ, Corby P, Kritchevsky SB, Harris TB, Rooks R, Rubin SM, Newman AB. Edentulism and nutritional status in a biracial sample of well-functioning community-dwelling elderly: the Health ABC Study. Am J Clin Nutr. 2004 Feb;79(2):295-302.

Weyant RJ, Newman AB, Kritchevsky SB, Bretz WA, Corby PM, Ren D, et al.
Periodontal disease and weight loss in older adults. J Am Geriatr Soc. 2004 Apr;52(4):547-53.

Weyant RJ, Pandav RS, Plowman JL, Ganguli M. Medical and cognitive correlates of denture wearing in older community-dwelling adults. J Am Geriatr Soc. 2004 Apr;52(4):596¬-600.

Weyant RJ, Manz M, Corby P. Dental caries status and need for dental treatment of Pennsylvania public school children in grades 1, 3, 9, and 11. J Pub Health Dent. 2004 Summer;64(3):136-44.

Famili P, Cauley JA, Suzuki JBS, Weyant, RJ. Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. J Periodontol. 2005 Jan;76(1):11-5.

Bretz WA, Corby PM, Hart TC, Costa S, Coelho MQ, Weyant RJ, Robinson M, Schork NJ. Dental caries and microbial acid production in twins. Caries Res. 2005 May-Jun;39(3):168-72.

Bretz WA, Weyant RJ, Corby PM, Ren D, Weissfeld L, Kritchevsky SB, Harris T, Kurella M, Satterfield S, Visser M, Newman AB. Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population. J Am Geriatr Soc. 2005 Sep;53(9):1532-7.

Corby PM, Lyons-Weller J, Bretz WA, Hart TC, Aas JA, Boumenna T, Goss J, Corby AL, Junior HM, Weyant RJ, Paster BJ. Microbial risk indicators in early childhood caries. J Clin Microbiol. 2005 Nov;43(11):5753-9.

Katancik JA, Kritchevsky S, Weyant RJ, Corby P, Bretz W, Crapo RO, Jensen R, Waterer G, Rubin SM, Newman AB. Periodontitis and airway obstruction. J Periodontol. 2005Nov;76(11 Suppl):2161-7.

Corby PM, Scheyler T; Spallek H, Hart TC, Weyant RJ, Corby AL, Bretz WA.
Using biometrics for participant identification in a research study: a case report. J Am Med Inform Assoc. 2006 Mar-Apr;13(2)233-5.

Mezzich, AC; Pager, KC; Day, B-H; Kirisci, L; Scholar, LJ; Bretz, WA; Corby, PM; Weyant, RJ. Maternal maltreatment, affective dysregulation, and oral health in children of fathers with and without substance disorder. J Child Maltreatment In Press.




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