Research Database
| Project Description | |||
| (submitted 02/10/2004) | |||
| Dentin Tissue Engineering | |||
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Contact Information:
3501 Terrace Street |
Principal Investigator: |
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Project Description: Gene delivery using non-viral approach is highly preferable due to convenience of delivery, ease of manufacturing, cost effectiveness, and biocompatibility. However, these techniques are limited by low transfection efficiency. To address this problem, we have developed nano-sized calcium phosphate particles, NanoCaPs, as a novel delivery system for plasmid DNA transfection. We hypothesize that NanoCaPs will serve as a superior transfection system because the reduced crystalline dimensions will result in increased surface-active DNA binding and greater cellular uptake and enhanced transfection efficiency. |
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Project Funding: |
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Please send comments to: Robert J. Weyant, DMD, DrPH: rjw1@pitt.edu
Division of Pediatric and Developmental Dental Sciences School of Dental Medicine University of Pittsburgh