• Pitt Dental Medicine Awarded $31 Million Grant for Translational Research

    Pitt Dental Medicine is Developing Transformative Therapies Michigan-Pittsburgh-Wyss Regenerative Medicine (MPWRM) Resource Center receives more than $31 million in federal funding to transform dental, oral, and craniofacial research into regenerative therapies. Drs. Charles Sfeir (right) and William Wagner (left) Read more >

  • Dr. Elia Beniash Awarded NIH Grant

    CCR faculty member, Elia Beniash, PhD, received a grant from the National Institutes of Health (NIH) entitled, "Function of Keratin 75 in Enamel." Proposed research will provide insights on the role of the protein Keratin 75 in structural organization, mechanical properties and caries susceptibility of dental enamel.

  • Dr. Dobrawa Napierala Receives NIH Grant

    CCR faculty member, Dobrawa Napierala, PhD, received a grant from the National Institutes of Health (NIH) entitled "Phosphate Signaling in Biomineralization." The project's goal is to delineate the signaling cascade that leads specifically to initiation of the mineralization process in response to elevated extracellular Pi.

  • Drs. Margolis and Beniash Awarded NIH Grant

    CCR faculty members, Henry Margolis, PhD, and Elia Beniash, PhD, received an NIH grant entitled, "Essential Role of Amelogenin Phosphorylation in Tooth Enamel Formation." This new R01 proposal is designed to elucidate the essential role the phosphorylation of a single amino acid in the most abundant enamel matrix protein, amelogenin, plays in the regulation of enamel formation.

  • Dr. Giuseppe Intini Awarded NIH Grant

    Giuseppe Intini, DDS, PhD, CCR faculty member, recently received a grant from the National Institutes of Health entitled, " Role and Regulation of PRX1 Expressing Cells During Calvarial Bone Regeneration."

  • Dr. Charles Sfeir Awarded NIH Grant

    CCR faculty member, Charles Sfeir, DDS, PhD, was awarded an NIH grant entitled, "Treatment of Periodontitis by Homing M2 Macrophages." This project seeks to further explore the therapeutic potential of M2 Macrophage induction by CC12 and to shed light on the mechanism underlying this process.

  • Dr. Mairobys Socorro Gonzalez Awarded NIH Grant

    Mairobys Socorro Gonzalez, PhD recently received a grant from the National Institutes of Health entitled, "Role of Mineralization-Regulating Transcription Factors in Susceptibility to Dental Caries." The proposed research will provide better understanding of the impact of genetic factors and molecular pathways regulating the process of tooth mineralization and how they affect susceptibility to dental caries.

  • Dr. Deborah Polk Awarded Food & Drug Administration (FDA) Grant

    Deborah Polk, PhD, recently received a grant from the Food and Drug Administration entitled, "Evidence-based Clinical Practice Guideline for the Management of Acute Dental Pain: Development, Implementation, and Evaluation Using Data Analytics to Target An Implementation Strategy." Read more about this exciting grant

Center for Craniofacial Regeneration

Rooted in ground-breaking tissue regeneration and biomaterial advances made at the University of Pittsburgh, the Center for Craniofacial Regeneration (CCR) develops treatments for wounds and defects of the face and skull that restore function and appearance. Representing many scientific disciplines and interests, our team is dedicated to exploring all aspects of the varied and complex craniofacial region. The CCR's dynamic approach draws upon the expertise of scientists, from cell and molecular biologists, polymer chemists and material scientists to bioengineers, imaging experts and clinicians. The CCR encourages the transfer of developed technologies and treatments to enable new biotechnology ventures. Recently awarded funding from the National Institutes of Health (NIH) to support a translational resource center bears this out, demonstrating how the work of centers, such as the CCR, ultimately can improve the lives of patients by bridging the gap between basic science and clinical treatments.
 

Center for Craniofacial Regeneration Mission

The Center for Craniofacial Regeneration is dedicated to the development of technologies and clinical therapies for craniofacial repair and regeneration. Our Center of Excellence is a global leader in this rapidly developing field. Our strength lies in the synergistic approach to translational research by clinicians, engineers and basic scientists. To meet these challenges, the CCR strives to foster multidisciplinary approaches to regenerate mineralized and soft tissues of craniofacial structures and employ tissue engineered strategies such as cellular therapies, biomaterials and mechanobiology. Our innovation has resulted in new and unique technologies developed by CCR members.
 

Michigan-Pittsburgh-Wyss Resource Center

The Center for Craniofacial Regeneration is part of the NIH/National Institute of Dental and Craniofacial Research (NIDCR)-funded Michigan-Pittsburgh-Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies. Over the course of three years, this translational resource center will pair developers of the most viable dental, oral and craniofacial regeneration therapies with those in the clinical, academic and private sectors to bring cutting edge discoveries into clinical practice for patient treatments. The resource center, with funding totaling about $14 million, is one of only two that have been funded this year by the NIDCR.

 

Research

The Center for Craniofacial Regeneration strives to foster multidisciplinary approaches to regenerate the mineralized and soft tissues of craniofacial structures, employing tissue engineered strategies such as cellular therapies, biomaterials, and mechanobiology. Read more >

CCR Resources

The CCR encourages the transfer of developed technologies and treatments to enable new biotechnology ventures providing jobs and a regional economic development.  Read more >

Our People

Our vibrant intellectual environment is committed to the academic excellence and career development of a diverse team of scientists and clinicians comprising faculty members, post-docs, fellows, graduate and undergraduate students, and visiting scholars. Read more >

Opportunities to Join our team

News and Events

Check out the Center's latest news. Read more >

Contact Us

We want to hear from you. CCR contact information, a map and driving directions can be found here >